/Tissue Engineering

Tissue Engineering

Portrait of Tissue Engineering
Lab Head: Lee Weiss
Mailing Address

Tissue Engineering is a multidisciplinary field that applies the principles of biology and engineering to develop tissue substitutes to restore, maintain, or improve the function of diseased or damaged human tissues. One approach for engineering tissue involves seeding biodegradable scaffolds with donor cells and/or growth factors, then culturing and implanting the scaffolds to induce and direct the growth of new, healthy tissue.

The need for bone substitutes is particularly important. Bone substitutes are often required to help repair or replace damaged or diseased tissues in cases ranging from trauma, to congenital and degenerative diseases, to cancer, to cosmetics. Our vision for creating tissue engineered bone is an advanced CAD/CAM (computer-aided-design/computer-aided-manufacturing) bioreactor system capable of growing large-scale, customized bone substitutes as depicted in the figure above. Our current research involves not only laying the foundation for several of the components required for realizing such an advanced system, but also gaining knowledge and developing components that will have clinical relevance in the nearer term.

Displaying 36 Publications
State Estimation for Humanoid Robots
Ben Xinjilefu

PhD Thesis, Tech. Report, CMU-RI-TR-15-20, Robotics Institute, Carnegie Mellon University, August, 2015
Toward an Automated System for the Analysis of Cell Behavior: Cellular Event Detection and Cell Tracking in Time-lapse Live Cell Microscopy
SeungIl Huh

PhD Thesis, Tech. Report, CMU-RI-TR-13-06, Robotics Institute, Carnegie Mellon University, March, 2013
Data-driven Prediction of Stem Cell Expansion Cultures
Zhaozheng Yin, Dai Fei Elmer Ker, Silvina Nanci Junkers, Takeo Kanade, Mei Chen, Lee Weiss and Phil Campbell

Conference Paper, 33rd Annual International Conference of the IEEE EMBS, November, 2011
Automated mitosis detection of stem cell populations in phase-contrast microscopy images
Seung-il Huh, D Ker, Ryoma Bise, Mei Chen and Takeo Kanade

Conference Paper, IEEE Trans. Med. Imaging, Vol. 30, No. 3, pp. 586 - 596, March, 2011
Cell Image Analysis: Algorithms, System and Applications
Takeo Kanade, Zhaozheng Yin, Ryoma Bise, SeungIl Huh, Sung Eun Eom, Michael Sandbothe and Mei Chen

Conference Paper, IEEE Workshop on Applications of Computer Vision (WACV) 2011, January, 2011
Mitosis detection for stem cell tracking in phase-contrast microscopy images
Seung-il Huh, Sungeun Eom, Ryoma Bise, Zhaozheng Yin and Takeo Kanade

Conference Paper, IEEE International Symposium on Biomedical Imaging, pp. 2121-2127, January, 2011
Reliable Cell Tracking By Global Data Association
Ryoma Bise, Zhaozheng Yin and Takeo Kanade

Conference Paper, IEEE International Symposium on Biomedical Imaging, January, 2011
Restoring Artifact-Free Microscopy Image Sequences
Zhaozheng Yin and Takeo Kanade

Conference Paper, IEEE International Symposium on Biomedical Imaging, January, 2011
Restoring DIC Microscopy Images from Multiple Shear Directions
Zhaozheng Yin, Dai Fei Elmer Ker and Takeo Kanade

Conference Paper, IEEE International Symposium on Biomedical Imaging, January, 2011
Spatially Directed Guidance of Stem Cell Population Migration by Immobilized Patterns of Growth Factor
Eric Miller, Kang Li, Takeo Kanade, L. Walker, Lee Weiss and Philip Campbell

Journal Article, Carnegie Mellon University, Biomaterials, Vol. 32, pp. 2775 - 2785, January, 2011
Understanding the Optics to Aid Microscopy Image Segmentation
Zhaozheng Yin, Kang Li, Takeo Kanade and Mei Chen

Conference Paper, International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) 2010, September, 2010
Heterogeneous Conditional Random Field: Realizing Joint Detection and Segmentation of Cell Regions in Microscopic Images
Jiyan Pan, Takeo Kanade and Mei Chen

Conference Paper, IEEE Conference on Computer Vision and Pattern Recognition (CVPR) 2010, June, 2010
Cell Segmentation in Microscopy Imagery Using a Bag of Local Bayesian Classifiers
Zhaozheng Yin, Ryoma Bise, Mei Chen and Takeo Kanade

Conference Paper, The IEEE International Symposium on Biomedical Imaging (ISBI) 2010, April, 2010
Detection of Hematopoietic Stem Cells in Microscopy Images Using a Bank of Ring Filters
Sung Eun Eom, Ryoma Bise and Takeo Kanade

Conference Paper, The IEEE International Symposium on Biomedical Imaging, April, 2010
Mitosis Sequence Detection Using Hidden Conditional Random Fields
An An Liu, K. Li and Takeo Kanade

Conference Paper, IEEE International Symposium on Biomedical Imaging (ISBI) 2010, April, 2010
Learning to Detect Different Types of Cells under Phase Contrast Microscopy
Jiyan Pan, Takeo Kanade and Mei Chen

Conference Paper, Microscopic Image Analysis with Applications in Biology (MIAAB) 2009, September, 2009
Reliably Tracking Partially Overlapping Neural Stem Cells in DIC Microscopy Image Sequences
Ryoma Bise, Kang Li, Sungeun Eom and Takeo Kanade

Conference Paper, MICCAI Workshop on Optical Tissue Image Analysis in Microscopy, Histopathology and Endoscopy (OPTMHisE), pp. 67-77, September, 2009
Cell Population Tracking and Lineage Construction with Spatiotemporal Context
Kang Li, Mei Chen, Takeo Kanade, Eric Miller, Lee Weiss and Phil Campbell

Journal Article, Carnegie Mellon University, Medical Image Analysis, Vol. 12, No. 5, pp. 546 - 566, October, 2008
Computer Vision Tracking of Stemness
Kang Li, Eric Miller, Mei Chen, Takeo Kanade, Lee Weiss and Phil Campbell

Conference Paper, Proc. IEEE International Symposium on Biomedical Imaging (ISBI): Special Session on In Vivo Microscopic Image Analysis, pp. 847 - 850, May, 2008
Cell Population Tracking and Lineage Construction Using Multiple-Model Dynamics Filters and Spatiotemporal Optimization
Kang Li and Takeo Kanade

Conference Paper, Proceedings of the 2nd International Workshop on Microscopic Image Analysis with Applications in Biology (MIAAB), September, 2007
Cell Population Tracking and Lineage Construction with Spatiotemporal Context
Kang Li, Mei Chen and Takeo Kanade

Conference Paper, Proceedings of the 10th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI), pp. 295 - 302, January, 2007
Online Tracking of Migrating and Proliferating Cells Imaged with Phase-Contrast Microscopy
Kang Li, Eric Miller, Lee Weiss, Phil Campbell and Takeo Kanade

Conference Paper, Proceedings of the 2006 Conference on Computer Vision and Pattern Recognition Workshop (CVPRW '06), pp. 65 - 72, June, 2006
Tracking of Migrating and Proliferating Cells in Phase-Contrast Microscopy Imagery for Tissue Engineering
Takeo Kanade and Kang Li

Conference Paper, Proceedings of the First International Workshop on Computer Vision for Biomedical Image Applications (CVBIA), October, 2005
Rabbit Calvarial Wound Healing Using Seeded Caprotite Scaffolds
Mark Mooney, Jay Calvert, Jeffrey O. Hollinger, Kacey Marra, Lee Weiss, Phil Campbell, Prashant Kumta and Sean Bidic

Journal Article, Journal of Dental Research, Vol. 82, No. 2, pp. 131 - 135, January, 2003
Prototype Implemtation of an Assembly System for Tissue Engineered Constructs
Martin Reischmann, R. Merz, Lawrence Schultz and Lee Weiss

Journal Article, Carnegie Mellon University, Elektrotechnik und Informationstechnik, pp. 248 - 252, July, 2002
Tissue Engineering: Solid Freeform Fabrication of Scaffolds
Lee Weiss

Journal Article, Science & Medicine, Vol. 8, No. 1, January, 2002
Solid Freeform Fabrication of Scaffolds for Tissue Engineering
Lee Weiss

Journal Article, Science & Medicine, January, 2001
Characterization of osteoblast-like behavior of cultured bone marrow stromal cells on various polymer surfaces
Jay W. Calvert, Kacey G. Marra, Lisa Cook, Prashant N. Kumta, Paul A. DiMilla and Lee Weiss

Journal Article, J. Biomed. Mat. Res., Vol. 52, No. 2, pp. 279 - 284, January, 2000
Modification of the Degradation of Polymer/Ceramic Scaffolds
A. S. Dunn, P. G. Campbell, Lee Weiss and K. G. Marra

Journal Article, J. Materials Science: Materials in Medicine, January, 2000
Stent-Based Gene Therapy
M. D. Feldman, B. Sun, B. J. Koci, C. C. Wu, J. R. Kneller, H. S. Borovetz, S. Watkings, A. Nadeem, Lee Weiss, M. L. Reed, A. J. C. Smith and W. Rosenblum

Journal Article, Journal of Long-Term Effects of Medical Implants, Vol. 10, No. 2-Jan, pp. 47 - 68, January, 2000
In Vitro analysis of biodegradable polymer blend/hydroxyapatite composites for bone tissue engineering
K. G. Marra, J. W. Szem, P. N. Kumta, P. A. DiMilla and Lee Weiss

Journal Article, J. Biomed. Mat. Res., Vol. 47, pp. 324 - 335, January, 1999
The Use of Microfabricated Probes to Penetrate the Internal Elastic Lamina and Intimal Hyperplasia
J. R. Kneller, C. C. Wu, D. A. Vorp, M. L. Reed, Lee Weiss, H. S. Borovetz, S. Watkins and M. D. Feldman

Journal Article, Journal of Cardiovascular Diagnosis & Procedures, Vol. 16, No. 2, pp. 37 - 50, January, 1999
Novel Three Dimensional Biodegradable Scaffolds for Bone Tissue Engineering
Kacey Marra, P. G. Campbell, P. A. DiMilla, Prashant Kumta, M. P. Mooney, Jeffrey Szem and Lee Weiss

Conference Paper, Materials Research Society Fall Meeting, December, 1998
Microfabricated Device for Intravascular Delivery
M. Feldman, J. Kneller, C. Wu, S. Watkins, Lee Weiss and M. L. Reed

Journal Article, Journal OfThe American College Of Cardiology, No. 31(2), February, 1998
Microfabricated Probes Can be Used to Administer Gene Therapy
M. D. Feldman, B. Sun, B. J. Koci, C. Wu, S. L. Castilla, A. Nadeem, Lee Weiss, M. L. Reed, A. J. C. Smith and W. Rosenblum

Journal Article, American Journal of Cardiology, No. 82(7A), pp. 28S - 29S, January, 1998
Micromechanical Devices for Intravascular Drug Delivery
M. L. Reed, C. C. Wu, J. R. Kneller, S. Watkins, D. A. Vorp, A. Nadeem, Lee Weiss, Keith Rebello, M. Mescher, A. J. C. Smith, W. Rosenblum and M. D. Feldman

Journal Article, Journal of Pharmaceutical Sciences, Vol. 87, No. 11, pp. 1387 - 1394, January, 1998
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