Precise Control of Osteogenesis for Craniofacial Defect Repair - The Role of Direct Osteoprogenitor Contact in BMP-2-Based Bioprinting - Robotics Institute Carnegie Mellon University

Precise Control of Osteogenesis for Craniofacial Defect Repair – The Role of Direct Osteoprogenitor Contact in BMP-2-Based Bioprinting

Darren M. Smith, James Cray, Lee Weiss, Dai Fei Elmer Ker, Sameer Shakir, S. Alex Rottgers, Joseph E. Losee, Philip Campbell, and Gregory Cooper
Journal Article, Annals of Plastic Surgery, Vol. 69, No. 4, pp. 485 - 488, October, 2012

Abstract

Success with bone morphogenetic protein-2 (BMP-2) has been widely reported in the osseous reconstruction of large calvarial defects. These efforts have required enormous doses of BMP-2 and are not sufficiently refined to facilitate the detail-oriented repair required for intricate craniofacial structures. We have previously shown that inkjet-based bioprinting technologies allow for precisely customized low-dose protein patterns to induce spatially regulated osteogenesis. Here, we investigate the importance of direct contact be- tween bioprinted BMP-2 and the dura mater (a source of osteoprogenitors) in mediating calvarial healing.

BibTeX

@article{Smith-2012-17114,
author = {Darren M. Smith and James Cray and Lee Weiss and Dai Fei Elmer Ker and Sameer Shakir and S. Alex Rottgers and Joseph E. Losee and Philip Campbell and Gregory Cooper},
title = {Precise Control of Osteogenesis for Craniofacial Defect Repair - The Role of Direct Osteoprogenitor Contact in BMP-2-Based Bioprinting},
journal = {Annals of Plastic Surgery},
year = {2012},
month = {October},
volume = {69},
number = {4},
pages = {485 - 488},
}