Inkjet-based biopatterning of SDF-1β augments BMP-2-induced repair of critical size calvarial bone defects in mice - Robotics Institute Carnegie Mellon University

Inkjet-based biopatterning of SDF-1β augments BMP-2-induced repair of critical size calvarial bone defects in mice

Samuel Herberg, Galina Kondrikova, Sudharsan Periyasamy-Thandavan, R. Nicole Howie, Mohammed E. Elsalanty, Lee Weiss, Phil Campbell, William D. Hill, and James J. Cray
Journal Article, Bone, Vol. 67, pp. 95 - 103, October, 2014

Abstract

A major problem in craniofacial surgery is non-healing bone defects. Autologous reconstruction re- mains the standard of care for these cases. Bone morphogenetic protein-2 (BMP-2) therapy has proven its clinical utility, although non-targeted adverse events occur due to the high milligram-level doses used. Ongoing efforts explore the use of different growth factors, cytokines, or chemokines, as well as co-therapy to augment healing. Methods: Here we utilize inkjet-based biopatterning to load acellular DermaMatrix delivery matrices with nanogram-level doses of BMP-2, stromal cell-derived factor-1β (SDF-1β), transforming growth factor-β1 (TGF-β1), or co-therapies thereof. We tested the hypothesis that bioprinted SDF-1β co-delivery enhances BMP-2 and TGF-β1-driven osteogenesis both in-vitro and in-vivo using a mouse calvarial critical size defect (CSD) model

BibTeX

@article{Herberg-2014-7907,
author = {Samuel Herberg and Galina Kondrikova and Sudharsan Periyasamy-Thandavan and R. Nicole Howie and Mohammed E. Elsalanty and Lee Weiss and Phil Campbell and William D. Hill and James J. Cray},
title = {Inkjet-based biopatterning of SDF-1β augments BMP-2-induced repair of critical size calvarial bone defects in mice},
journal = {Bone},
year = {2014},
month = {October},
volume = {67},
pages = {95 - 103},
keywords = {Bone, Healing, Biopatterning, BMP-2. SDF-1β, TGF-β1},
}