Percutaneous intracerebral navigation by duty-cycled spinning of flexible bevel-tipped needles

Johnathan A. Engh, Davneet Minhas, Douglas Kondziolka, and Cameron Riviere
Neurosurgery, Vol. 67, No. 4, October, 2011, pp. 1117-1123.


Abstract
BACKGROUND: Intracerebral drug delivery using surgically placed microcatheters is a growing area of interest for potential treatment of a wide variety of neurological diseases, including tumors, neurodegenerative disorders, trauma, epilepsy, and stroke. Current catheter placement techniques are limited to straight trajectories. The development of an inexpensive system for flexible percutaneous intracranial navigation may be of significant clinical benefit. OBJECTIVE: Utilizing duty-cycled spinning of a flexible bevel-tipped needle, the authors devised and tested a means of achieving nonlinear trajectories for the navigation of catheters in the brain, which may be applicable to a wide variety of neurological diseases. METHODS: Exploiting the bending tendency of bevel-tipped needles due to their asymmetry, the authors devised and tested a means of generating curvilinear trajectories by spinning a needle with a variable duty cycle (i.e., in on-off fashion). The technique can be performed using image guidance, and trajectories can be adjusted intraoperatively via joystick. Fifty-eight navigation trials were performed during cadaver testing to demonstrate the efficacy of the needle-steering system and to test its precision. RESULTS: The needle-steering system achieved a target acquisition error of 2 +/- 1 mm, while demonstrating the ability to reach multiple targets from one burr hole using trajectories of varying curvature. CONCLUSION: The accuracy of the needle-steering system was demonstrated in a cadaveric model. Future studies will determine the safety of the device in vivo.

Keywords
Chemotherapy, Drug delivery, Intracerebral navigation

Notes
Sponsor: The Simeon M. Jones, Jr. and Katharine Reed Jones Fund and the Walter L. Copeland Fund of The Pittsburgh Foundation
Associated Center(s) / Consortia: Medical Robotics Technology Center
Associated Lab(s) / Group(s): Surgical Mechatronics Laboratory
Associated Project(s): Needle Steering for Brain Surgery

Text Reference
Johnathan A. Engh, Davneet Minhas, Douglas Kondziolka, and Cameron Riviere, "Percutaneous intracerebral navigation by duty-cycled spinning of flexible bevel-tipped needles," Neurosurgery, Vol. 67, No. 4, October, 2011, pp. 1117-1123.

BibTeX Reference
@article{Engh_2011_6916,
   author = "Johnathan A Engh and Davneet Minhas and Douglas Kondziolka and Cameron Riviere",
   title = "Percutaneous intracerebral navigation by duty-cycled spinning of flexible bevel-tipped needles",
   journal = "Neurosurgery",
   pages = "1117-1123",
   publisher = "Lippincott Williams & Wilkins",
   month = "October",
   year = "2011",
   volume = "67",
   number = "4",
}