The Robotics Institute

Carnegie Mellon Robotics Institute

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Abstract

Purpose. To assess the performance of standard image registration techniques for automated MRI-based segmentation of the hippocampus in elderly subjects with Alzheimer?s Disease (AD) and mild cognitive impairment (MCI). Methods. Structural MR images of 54 age- and gender-matched healthy elderly individuals, subjects with probable AD, and subjects with MCI were collected at the University of Pittsburgh Alzheimer?s Disease Research Center. Hippocampi in subject images were automatically segmented by using AIR, SPM, FLIRT, and the fully-deformable method of Chen to align the images to the Harvard atlas, MNI atlas, and randomly-selected, manually-labeled subject images. Mixed-effects statistical models analyzed the effects of side of the brain, disease state, registration method, choice of atlas, and manual tracing protocol on the agreement between automated segmentations and expert manual segmentations. Results. Registration methods that produced higher degrees of geometric deformation produced automated segmentations with higher agreement with manual segmentations. Automated-manual agreement between Chen?s method and expert manual segmentations were competitive with manual-manual agreement. Segmentations of the right hippocampus were more consistent with manual segmentations than those of the left. Automated-manual agreement was significantly lower in AD brains than MCI or controls. Automated segmentations based on registration with a randomly-selected subject image were more consistent with manual segmentations than those based on registration with the Harvard or MNI atlas. The manual tracing protocol was a significant source of variation in automated-manual agreement.

Notes

Associated Center(s) / Consortia: Vision and Autonomous Systems Center and Medical Robotics Technology Center

Associated Lab(s) / Group(s): Biomedical Image Analysis

Associated Project(s): Predicting Risk of Alzheimer's Disease From Shape Features

Number of pages: 45

Text Reference

Owen Carmichael, Howard Aizenstein, Simon W. Davis, Jim Becker, Paul M. Thompson, Carolyn Meltzer, and Yanxi Liu, "Atlas-Based Hippocampus Segmentation In Alzheimer's Disease and Mild Cognitive Impairment," tech. report CMU-RI-TR-04-53, Robotics Institute, Carnegie Mellon University, December, 2004

BibTeX Reference

@techreport{Carmichael_2004_4866,
   author = "Owen Carmichael, Howard Aizenstein, Simon W. Davis, Jim Becker, Paul M. Thompson, Carolyn Meltzer, and Yanxi Liu",
   title = "Atlas-Based Hippocampus Segmentation In Alzheimer's Disease and Mild Cognitive Impairment",
   institution = "Robotics Institute",
   month = "December",
   year = "2004",
   number= "CMU-RI-TR-04-53",
   address= "Pittsburgh, PA",
}

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